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Article: Reports outline zebrafish research from J.T.M.L. Paridaen and colleagues.(Report)
- Article from:
- Ecology, Environment & Conservation
- Article date:
- June 26, 2009
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According to recent research published in the journal Zebrafish, "The tumor suppressor Apc1 is an intracellular antagonist of the Wnt/beta-catenin pathway. We examined the effects of an Apc1 loss-of-function mutation on retino-tectal axon pathfinding in zebrafish."
"In apc mutants, the retina is disorganized and optic nerves portray pathfinding defects at the optic chiasm and do not project properly to the tectum. Wild-type cells, transplanted into mutant retinae, acquire retinal ganglion cell fate and project axons that cross at the mispositioned optic chiasm and extend to the contralateral tectum, suggesting a function of apc1 in axon pathfinding. These defects ...