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Article: Findings from Charite University provide new insights into stem cell research.(Report)
- Article from:
- Biotech Week
- Article date:
- July 8, 2009
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"Embryonic stem cells (ESC) are suggested to be immune-privileged, but they carry the risk of uncontrolled expansion and malignancy. Upon differentiation they lose their tumor-forming capacity, but they become immunogenic by the expression of a normal set of MHC molecules," scientists writing in the journal Cell Research report (see also Stem Cell Research).
"This immunogenicity might trigger rejection after application in regenerative therapies. In this study MHC expression of and immune responses to endothelial derivatives of rat embryonic stem cell-like cells (RESC) under inflammatory conditions were determined in comparison to primary rat aortic endothelial ...