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Article: Studies by K. Kitatani and co-authors describe new findings in enzyme research.
- Article from:
- Cancer Weekly
- Article date:
- July 7, 2009
CopyrightCOPYRIGHT 2009 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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"Activation of protein kinase C (PKC) by the phorbol ester (phorbol 12-myristate 13-acetate) induces ceramide formation through the salvage pathway involving, in part, acid beta-glucosidase 1 (GBA1), which cleaves glucosylceramide to ceramide. Here, we examine the role of the GBA1-ceramide pathway, in regulating a pro-inflammatory pathway initiated by PKC and leading to activation of p38 and induction of interleukin 6 (IL-6)," scientists in the United States report (see also Enzyme Research).
"Inhibition of ceramide formation by fumonisin B1 or down-regulation of PKC delta potentiated PMA-induced activation of p38 in human breast cancer MCF-7 cells. Similarly, ...
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Article: Research reports on enzyme research from Weizmann ...
Biotech Week;
August 20, 2008 ;
700+ words
... ... Department of Biological Chemistry (see also Enzyme Research). The researchers ... Dept. of Biological Chemistry, Rehovot 76100 ... Biochemistry, Biological Chemistry, Caspase ... Supplement, Drugs, Enzyme Research, Glutathione ...
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