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Article: Research results from A.M. Amin and co-authors update knowledge of radioanalytical and nuclear chemistry.
- Article from:
- Chemicals & Chemistry
- Article date:
- July 24, 2009
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"The present study is performed to compare the electrophilic substitution radioiodination reaction of two non-steroidal anti-inflammatory drugs namely, Piroxicam (Pirox) and Meloxicam (Melox) with I-125 where both chloramine-T (CAT) and iodogen were used as oxidizing agents. The factors affecting the percent of radiochemical yields such as drug concentration, pH of the reaction mixtures, different oxidizing agents, reaction time, temperature and different organic media were studied to optimize the conditions for labeling of Pirox and Melox and to obtain high radiochemical yields," scientists in Cairo, Egypt report.
"The maximum radiochemical yield of ...