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Article: Comparison of anorexia, lethargy, and fever induced by bacterial and viral mimetics in rats.(Report)
- Article from:
- Canadian Journal of Physiology and Pharmacology
- Article date:
- March 1, 2009
- Author:
CopyrightCOPYRIGHT 2009 NRC Research Press. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Introduction
Fever and sickness behaviors, such as anorexia and decreased activity, are common clinical features of bacterial infections in sick humans and animals (Hart 1988; Plata-Salaman 1996; Cartmell et al. 2002; Escobar et al. 2007). Although the presence of fever and sickness behavior appears to be a common feature of bacterial infections, it has been noted experimentally that these sickness responses present differently depending on whether gram-positive or gram-negative bacterial products are administered (Gayle et al. 1998; Plata-Salaman et al. 1998; Cartmell et al. 2002). In particular it has been noted that muramyl dipeptide (MDP) from gram-positive ...
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