Article: Major Congenital Malformations after First-Trimester Exposure to ACE Inhibitors.

Major Congenital Malformations after First-Trimester Exposure to ACE Inhibitors

Abstract & Commentary

By John C. Hobbins, MD, Professor and Chief of Obstetrics, University of Colorado Health Sciences Center, Denver, is Associate Editor for OB/GYN Clinical Alert.

Dr. Hobbins reports no financial relationship to this field of study.

Synopsis: Exposure to ACE inhibitors during the first trimester cannot be considered safe and should be avoided.

Source: Cooper WO, et al. Major congenital malformations after first-trimester exposure to ACE inhibitors. N Engl J Med. 2006;354:2443-2451.

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