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Article: Studies from University of Calgary describe new findings in enzyme research.
- Article from:
- Biotech Week
- Article date:
- August 12, 2009
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According to recent research from Calgary, Canada, "Vascular smooth muscle Kv1 delayed rectifier K+ channels (K-DR) containing Kv1.2 control membrane potential and thereby regulate contractility. Vasodilatory agonists acting via protein kinase A (PKA) enhance vascule smooth muscle Kv1 activity, but the molecular basis of this regulation is uncertain."
"We characterized the role of a C-terminal phosphorylation site, Ser-449, in Kv1.2 expressed in HEK 293 cells by biochemical and electrophysiological methods. We found that 1) in vitro phosphorylation of Kv1.2 occurred exclusively at serine residues, 2) one major phosphopeptide that co-migrated with (449)pSASTISK ...
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Article: Research reports on enzyme research from Weizmann ...
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