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Article: New chemistry research from K. Padiya and colleagues discussed.
- Article from:
- Chemicals & Chemistry
- Article date:
- August 14, 2009
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According to recent research from Bombay, India, "A practical route for the synthesis of [R]-fluoxetine center dot HCl (ee=96%) in 56% overall yield was described."
"The key intermediate [R]-3-chloro-1-phenyl-1-propanol was obtained by the asymmetric reduction of prochiral 3-chloropropiophenone using in-situ generated oxazaborolidine catalyst derived from (S)-alpha,alpha-diphenylprolinol. The chiral procatalyst (S)-alpha,alpha-diphenylprolinol was recovered quantitatively and recycled," wrote K. Padiya and colleagues.
The researchers concluded: "An improved practical synthesis of (S)-alpha,alpha-diphenylprolinol was also discussed."
Padiya and ...