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Article: Studies by F.D. Shi and co-authors describe new findings in central nervous system disorders.(Report)
- Article from:
- Pain & Central Nervous System Week
- Article date:
- March 30, 2009
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According to recent research published in the Journal of Immunology, "The expression of nicotinic acetylcholine receptors by neurons, microglia, and astrocytes suggests possibly diverse mechanisms by which natural nicotinic cholinergic signaling and exposure to nicotine could modulate immune responses within the CNS. In this study, we show that nicotine exposure significantly delays and attenuates inflammatory and autoimmune responses to myelin Ags in the mouse experimental autoimmune encephalomyelitis model."
"In the periphery, nicotine exposure inhibits the proliferation of autoreactive T cells and alters the cytokine profile of helper T cells. In the CNS, ...