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Article: Studies from E.D. Kharasch et al add new findings in the area of anesthesiology.
- Article from:
- Pain & Central Nervous System Week
- Article date:
- July 6, 2009
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"Sevoflurane is produced by several manufacturers. Currently marketed sevoflurane formulations differ in their method of synthesis, impurities, containers in which they are sold, and water content," investigators in the United States report (see also Anesthesiology).
"Of the various types of chemical degradation to which sevoflurane is susceptible, the most pertinent is degradation by Lewis acids (such as metal oxides and metal halides) to hydrofluoric acid and other toxic compounds. Water inhibits such degradation. This observational study determined the degradation profile of three formulations of sevoflurane (two lower-water and one higher-water formulation) ...