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Article: New metabolism findings from University of Munich published.
- Article from:
- Cancer Weekly
- Article date:
- August 18, 2009
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"Exposure to the tobacco-specific N-nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is considered to be an important etiological risk factor for lung cancer in tobacco users. The metabolism of NNK via carbonyl reduction to 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), alpha-hydroxylation to form both DNA methylating and pyridyloxobutylating intermediates, and detoxification by pyridyl N-oxidation and glucuronide formation are well-characterized in laboratory animals but less so in man," researchers in Munich, Germany report (see also Metabolism).
"The in vitro kinetics of 0.03-250 mc M [5(-3)H]NNK metabolism were determined under ...