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Article: Reports from S. Napoli and colleagues advance knowledge in molecular and cellular biology.
- Article from:
- Science Letter
- Article date:
- August 18, 2009
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"Small interfering RNAs (siRNAs) directed to gene promoters can silence genes at the transcriptional level. siRNA-directed transcriptional silencing (RdTS) was first described in plants and yeasts and more recently in mammalian cells. RdTS has been associated with the induction of epigenetic changes and the formation of complexes containing RNA interference and chromatin-remodelling factors," scientists in Bellinzona, Switzerland report (see also Molecular and Cellular Biology).
"Here, we show that a promoter-targeted siRNA inhibits transcription of the c-myc gene. Transcriptional silencing of c-myc did not involve changes of known epigenetic marks. Instead, the ...