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Article: Turning p53 on, off may aid in avoiding radiation’s damage.
- Article from:
- Diagnostics & Imaging Week
- Article date:
- September 14, 2006
CopyrightCOPYRIGHT 2006 A Thomson Healthcare Company. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Making an omelet without a hammer
Turning p53 on, off may aid in avoiding radiation?s damage
By ANETTE BREINDL
Diagnostics & Imaging Week Science Editor
One of the ironies of cancer is that patients generally feel worse after treatment than before; radiation and chemotherapy induce widespread cell death, by activating the DNA damage response via what is known as p53.
P53?s claim to fame is that it is a tumor suppressor, and so conventional wisdom holds that you can?t make an omelet without breaking eggs: chemotherapy?s and radiation?s side effects are ?generally deemed an unfortunate but unavoidable consequence of the role p53 ...