Article: Clopidogrel or Aspirin Plus Esomeprazole with GI Bleeding.

Clopidogrel or Aspirin Plus Esomeprazole with GI Bleeding

Abstract & Commentary

Synopsis: In patients with healed upper GI lesions that had caused bleeding and who needed antiplatelet therapy for cardiovascular reasons, aspirin plus esomeprazole was superior to clopidogrel for preventing recurrent upper GI bleeding.

Source: Chan FKL, et al. N Engl J Med. 2005;352:238-244.

In patients with cardiovascular indications for chronic antiplatelet therapy, but a history of upper gastrointestinal (GI) bleeding, there are 2 recommended alternatives: clopidogrel or aspirin plus a proton-pump inhibitor. Although the ACC/AHA guidelines recommend ...

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