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Article: Clopidogrel or Aspirin Plus Esomeprazole with GI Bleeding.
- Article from:
- Clinical Cardiology Alert
- Article date:
- March 1, 2005
CopyrightCOPYRIGHT 2005 A Thomson Healthcare Company. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Clopidogrel or Aspirin Plus Esomeprazole with GI Bleeding
Abstract & Commentary
Synopsis: In patients with healed upper GI lesions that had caused bleeding and who needed antiplatelet therapy for cardiovascular reasons, aspirin plus esomeprazole was superior to clopidogrel for preventing recurrent upper GI bleeding.
Source: Chan FKL, et al. N Engl J Med. 2005;352:238-244.
In patients with cardiovascular indications for chronic antiplatelet therapy, but a history of upper gastrointestinal (GI) bleeding, there are 2 recommended alternatives: clopidogrel or aspirin plus a proton-pump inhibitor. Although the ACC/AHA guidelines recommend ...