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Article: Spinonolactone Post Myocardial Infarction.
- Article from:
- Clinical Cardiology Alert
- Article date:
- July 1, 2003
CopyrightCOPYRIGHT 2003 A Thomson Healthcare Company. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Spinonolactone Post Myocardial Infarction
Abstracts & Commentary
Since aldosterone is extracted by the heart following acute myocardial infarction (MI), this group of investigators from Japan hypothesized that blocking its action may attenuate postinfarction remodeling. Thus, they studied 150 patients admitted for their first acute MI who were successfully treated by percutaneous coronary interventions. They were randomized to receive the mineralocorticoid receptor blocker canrenoate intravenously early after catheterization followed by spironolactone 25 mg/d or no aldosterone blocker. All patients were given enalapril 2.5 mg/d, which was up-titrated to ...