Article: Wild Yam and Progesterone Creams.

Wild Yam and Progesterone Creams

By Adriane Fugh-Berman, MD, and Anthony R. Scialli, MD

Topical transdermal progesterone and wild yam creams have been promoted for treating osteoporosis, hot flashes, and PMS, as well as for preventing breast cancer. Additionally, some alternative medicine practitioners recommend transdermal progesterone creams as the progestin component of hormone replacement therapy, often in conjunction with estriol or tri-estrogen (estrone, estradiol, and estriol, typically in a 1:1:8 ratio). Natural (micronized) progesterone is derived from diosgenin in soybeans (Glycine max) or an inedible Mexican wild yam (Diascorea villosa).

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