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Article: How HAPE Happens.
- Article from:
- Travel Medicine Advisor
- Article date:
- June 1, 2002
CopyrightCOPYRIGHT 2002 A Thomson Healthcare Company. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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How HAPE Happens
Abstracts & Commentary
Synopsis: Recent studies suggest that high-altitude pulmonary edema (HAPE) is not primarily an inflammatory process, but that it might result from alterations in the sodium-driven clearance of alveolar fluid. In addition to gradual ascent, prophylactic salmeterol might be effective in travelers who are predisposed to HAPE.
Sources: Swenson ER, et al. Pathogenesis of high-altitude pulmonary edema: Inflammation is not an etiologic factor. JAMA. 2002;287:2228-2235; Sartori C, et al. Salmeterol for the prevention of high-altitude pulmonary edema. N Engl J Med. 2002;346:1631-1636.
To determine whether ...