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Article: Research reports on life sciences from Biotechnology Research Center, Department of Molecular Medicine provide new insights.(Report)
- Article from:
- Blood Weekly
- Article date:
- September 3, 2009
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New research, 'Detection of unknown deletions in beta-globin gene cluster using relative quantitative PCR methods,' is the subject of a report. According to recent research from Iran, "beta-Thalassemia is mainly caused by mutations involving single base substitution and small deletions. However, a considerable number of carriers are suspected to have large deletions in beta-globin gene cluster."
"Common strategy for identifying deletions with definite breakpoints is based on Gap PCR. There are, however, some cases with indefinite breakpoints which usually cannot be detected by this method. We developed and optimized a quantitative real-time PCR assay for copy ...