Article: Pharmacologic Calvinism: Why Drugs Should Be Used for Indications, Not Side Effects.

Pharmacologic Calvinism: Why Drugs Should Be Used for Indications, Not Side Effects

Abstract & Commentary

Synopsis: Diphenhydramine was associated with significantly increased risk of inattention, disorganized speech, altered consciousness, urinary retention, and increased length of stay in hospitalized patients older than 70 years.

Source: Agostini JV, et al. Arch Intern Med. 2001;161:2091-2097.

Agostini and colleagues, who were funded by the National Institute on Aging, undertook a prospective study of adverse effects of diphenhydramine (Benadryl) in hospitalized patients older than the age of 70 years. They hypothesized that this ...

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