|
|
Article: Chemoprevention of Second Primary Lung Cancers.
- Article from:
- Clinical Oncology Alert
- Article date:
- June 1, 2001
CopyrightCOPYRIGHT 2001 A Thomson Healthcare Company. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
|
Chemoprevention of Second Primary Lung Cancers
Abstract & Commentary
Synopsis: Animal models have shown that vitamin A can reverse squamous metaplasia in the setting of vitamin A deficiency. Furthermore, published data from a randomized trial from Milan showed that patients who took vitamin A following treatment for stage I non-small cell lung cancer realized a statistically significant decrease in second primary tumors of the upper aerodigestive tract. An NCI-sponsored, randomized, intergroup placebo-controlled trial based on these types of data sought to confirm whether, indeed, second primary tumors and recurrences could be prevented with adjuvant ...