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Article: Subcutaneous Sumatriptan Injection for the Acute Treatment of Migraine.(Clinical report)
- Article from:
- Neurology Alert
- Article date:
- January 1, 2000
CopyrightCOPYRIGHT 2000 A Thomson Healthcare Company. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Subcutaneous Sumatriptan Injection for the Acute Treatment of Migraine
abstract & commentary
Source: OQuinn S, et al. Prospective large-scale study of the tolerability of subcutaneous sumatriptan injection for the acute treatment of migraine. Cephalalgia 1999;19:223-231.
The new 5-ht 1d/1b agonists have revolutionized the treatment of migraine. The mechanism of action appears to be both the inhibition of neurogenic inflammation by binding to presynaptic 1D receptors on trigeminal afferents and vasoconstriction through action at the post-synaptic 1B receptors on cerebral blood vessels. Sumatriptan has been the prototype of the class and the only ...