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Article: Effects of Sertraline on Platelet Functioning in Depressed Patients.
- Article from:
- Psychiatric Medicine in Primary Care
- Article date:
- July 1, 2000
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Effects of Sertraline on Platelet Functioning in Depressed Patients
Abstract & commentary
Source: Markovitz JH, et al. Platelet activation in depression and effects of sertraline treatment: An open-label study. Am J Psychiatry 2000;57:1006-1008.
One of the interesting biologic findings in the link between depression and cardiovascular disease has been that depressed patients exhibit a greater amount of platelet activation when compared to euthymic (nondepressed) patients. Such an effect on platelets may well contribute to the development, or worsening, of endothelial damage to coronary vasculature, and hence the increased mortality rates after ...