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Article: Control of Steroid Hormone Receptor Action.
- Article from:
- Cancer Research Alert
- Article date:
- February 1, 2000
CopyrightCOPYRIGHT 2000 AHC Media LLC. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Control of Steroid Hormone Receptor Action
By Bekir Cinar, DVM, and Robert A. Sikes, PhD
Steroid hormones regulate many physiological processes that include: male and female reproduction, cellular proliferation, cellular differentiation, cell death, and homeostasis. The action of these lipophilic steroid hormones is mediated by steroid hormone receptors (SHRs) that, when bound to their cognate steroidal ligand, are transmuted into activated transcription factors. Steroids have long been thought to play a role in the etiology of cancers arising in hormonally responsive tissues like breast and prostate.
In breast cancer, one of the longest ...