Article: Antenatal Diagnosis of Fetal RhD Status.(Rhesus disease)(Report)

Antenatal Diagnosis of Fetal RhD Status

ABSTRACT & COMMENTARY

Synopsis: It is possible to determine the Rhesus (hemolytic) disease (RhD) status of fetuses of RhD-negative women after the first trimester of pregnancy, using a sensitive molecular polymerase chain reaction technique that can detect and characterize minute quantities of fetal DNA in the mothers plasma.

Source: Lo YMD, et al. Prenatal diagnosis of fetal RhD status by molecular analysis of maternal plasma. N Engl J Med 1998;339:1734-1738.

The rhesus (hemolytic) disease (rhd) gene has been identified and cloned and is absent in RhD-negative individuals. Beginning early in ...

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