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Article: Prevention of Colitis- Associated Colon Cancer.
- Article from:
- Cancer Research Alert
- Article date:
- September 1, 1999
CopyrightCOPYRIGHT 1999 AHC Media LLC. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Prevention of Colitis- Associated Colon Cancer
By M.L.Clapper, PhD; H. S. Cooper, MD; and S. Murthy, PhD
Inflammatory bowel disease (ibd) continues to affect approximately one million individuals in the United States..sup.1 Although the high incidence of colorectal cancer among these IBD patients has been well established, the molecular basis for this increased risk remains unknown. The animal model of dextran sulfate sodium (DSS)-induced colitis provides a unique opportunity to evaluate the sequence of biochemical and histological changes that lead to dysplasia and cancer. The similarity of DSS-induced colitis to human disease makes this model a ...