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Article: Role of Copper in the Genesis of Liver Cancer.

Article from:
Cancer Research Alert
Article date:
September 1, 1999
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Role of Copper in the Genesis of Liver Cancer

By Kalipatnapu N. Rao, PhD, and Patricia K. Eagon, PhD

Many chemicals are carcinogenic to liver in rodents, some of which are also suspected to cause liver cancer in humans. These chemicals include common household and industrial agents as well as agricultural chemicals, pesticides, herbicides, and several therapeutic drugs that have wide human exposure and use. Experimental rodent models of liver cancer developed in our laboratory, as well as human liver specimens, demonstrate alterations in copper metabolism and accumulation of excess copper. Copper is an essential element and its levels are tightly ...

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