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Article: Findings in enzyme research reported from University of California.
- Article from:
- Biotech Week
- Article date:
- September 9, 2009
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According to recent research published in the journal Chembiochem, "The double hydroxylation of 6-pretetramid to 4-keto-anhydro-tetracycline is a key tailoring reaction during the biosynthesis of the broad-spectrum antibiotic tetracyclines. It has been shown previously by heterologous reconstitution that OxyL is a dioxygenase and is the only enzyme required to catalyze the insertion of oxygen atoms at the C-12a and C-4 positions."
"We report here that OxyE, a flavin adenine dinucleotide (FAD)-dependent hydroxylase homologue, is an ancillary mono-oxygenase for OxyL during oxytetracycline biosynthesis in Streptomyces rimosus. By using both gene disruption and ...
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