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Article: Research from University of Gottingen yields new findings on circadian rhythm sleep disorders.
- Article from:
- Clinical Trials Week
- Article date:
- September 7, 2009
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"Tasimelteon, developed by Vanda Pharmaceuticals Inc under license from Bristol-Myers Squibb Co, is a melatonin receptor agonist. Because of the high density of melatonin receptors in the circadian pacemaker, the suprachiasmatic nucleus, melatonergic actions can phase-shift circadian rhythms and promote sleep," researchers in Germany report (see also Circadian Rhythm Sleep Disorders).
"Tasimelteon was effective in reducing sleep onset latency (in phase II and III clinical trials) and in resetting the circadian melatonin rhythm (in phase II trials), which indicated its potential suitability as treatment for jet lag, shift work and circadian rhythm sleep disorders. ...