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Article: Research from University of Minnesota reveals new findings on immunology.(Report)
- Article from:
- Immunotherapy Weekly
- Article date:
- September 16, 2009
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According to recent research from the United States, "The contribution of peripheral expression of tissue-specific CNS Ags to the generation of tolerance is uncertain. To study this question, we examined mice transgenic (Tg) for expression of beta-galactosidase (beta gal) on the retinal photoreceptor cell arrestin promoter, in conjunction with TCR Tg mice producing CD4(+) T cells specific for beta gal (beta galTCR)."
"Several strategies were used to test the hypothesis that beta gal expressed in the retina supported thymus-independent tolerance and regulatory T cell development. Retinal expression generated an immunoregulatory response that depressed development ...