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Article: New tuberculosis study findings have been reported from J. Vaubourgeix et al.
- Article from:
- Obesity, Fitness & Wellness Week
- Article date:
- September 19, 2009
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According to a study from Toulouse, France, "S-Adenosylmethionine- dependent methyltransferases (Ado-Met-MTs) constitute a large family of enzymes specifically transferring a methyl group to a range of biologically active molecules. Mycobacterium tuberculosis produces a set of paralogous AdoMet-MTs responsible for introducing key chemical modifications at defined positions of mycolic acids, which are essential and specific components of the mycobacterial cell envelope."
"We investigated the inhibition of these mycolic acid methyltransferases (MA-MTs) by structural analogs of the AdoMet cofactor. We found that S-adenosyl-N-decyl-aminoethyl, a molecule in which ...