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Article: Oral supplements delay ESRD: sodium bicarbonate slows creatinine clearance declines in CKD patients.(Clinical report)
- Article from:
- Renal & Urology News
- Article date:
- September 1, 2009
- Author:
CopyrightCOPYRIGHT 2009 Haymarket Media, Inc. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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CKD PATIENTS who took oral sodium bicarbonate supplements slowed their progression to end-stage renal disease (ESRD) and improved their nutritional status, according to a British study that researchers say is the first randomized, controlled trial to show these positive effects.
The researchers, led by Muhammad M. Yaqoob, MD, Professor of Nephrology at Barts and the London NHS Trust in London, recruited 134 adult CKD patients (creatinine clearance [CrCl] 15-30 mL/min/1.73 [m.sup.2]) and serum bicarbonate levels of 16-20 mmol/L. They randomly assigned 67 patients to receive supplementation with oral sodium bicarbonate (600 mg tablets three times daily increased as ...