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Article: Alpha-immunotherapy in cancer treatment. (Institute for Transuranium Elements develops radionuclide generator)

Article from:
The BBI Newsletter
Article date:
June 1, 1998
Author:
Copyright

The Institute for Transuranium Elements (ITV; Karlsruhe, Germany) has developed radionuclide generators specially designed to produce alpha particle-emitting radionuclides for cancer therapy.

Alpha-immunotherapy uses bismuth-213 (Bi-213) attached to a monoclonal antibody which targets bone marrow, liver and spleen. The radionuclide delivers high-powered, short-range alpha particle radiation. Trials at the Memorial Sloan-Kettering Cancer Center (New York) have shown that alpha particles are 100 to 1,000 times more cytotoxic than beta particles and cause less damage to surrounding ...

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