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Article: Reports by Y.Z. Wu and co-researchers describe recent advances in cardiology.(Report)
- Article from:
- Biotech Week
- Article date:
- September 23, 2009
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"Palmitoyl-L-carnitine (PC), an ischemic metabolite, causes cellular Na+ and Ca2+ overload and cardiac dysfunction. This study determined whether ranolazine [(+/-)-1-piperazineacetamide, N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-] attenuates PC-induced Na+ current and ventricular contractile dysfunction of the isolated heart," researchers in the United States report (see also Cardiology).
"PC (4 mc M, 30 min) increased late Na+ current by 1034 +/- 349% in guinea pig isolated ventricular myocytes; ranolazine (10 mc M) and tetrodotoxin (TTX, 3 mc M) significantly attenuated this effect of PC. PC increased left ventricular end-diastolic ...