Article: Study results from Mayo Clinic broaden understanding of physiology.

"Keenan DM, Roelfsema F, Carroll BJ, Iranmanesh A, Veldhuis JD. Sex define the age dependence of endogenous ACTH-cortisol dose responsiveness," scientists writing in the American Journal of Physiology - Regulatory Integrative and Comparative Physiology report (see also Physiology).

"Am J Physiol Regul Integr Comp Physiol 297: R515-R523, 2009. First published June 17, 2009; doi:10.1152/ajpregu.00200.2009.-Sex influences adrenal glucocorticoid responses to ACTH in experimental animals. Whether similar sex differences operate in humans is unknown. To test this notion, we estimated ACTH-cortisol dose-response properties analytically in 48 healthy adults (n = 22 ...

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