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Article: Findings from University of Manitoba provide new insights into sensorineural hearing loss.(Report)
- Article from:
- Biotech Week
- Article date:
- September 23, 2009
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"A possible medical treatment for sensorineural hearing loss using brain-derived nerve growth factor (BDNF) was explored. The hypothesis is that direct intracochlear application of BDNF will result in improved hearing," scientists writing in the journal Laryngoscope report (see also Sensorineural Hearing Loss).
"Animal research study. Significant hearing loss was created using cisplatin in 11 guinea pigs. One month later, bilateral cochleostomies were performed placing 0.05 mu g of BDNF in one cochlea of each animal prior to plugging with connective tissue. The other cochlea served as a control. Auditory brain-stem response (ABR) testing was then carried out for ...