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Article: Study data from University of Ferrara provide new insights into hematology.
- Article from:
- Blood Weekly
- Article date:
- September 24, 2009
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"Folate and its derivatives are pivotal for cell cycle and proliferation. They facilitate the crosstalk between DNA synthesis and melthylation crucial processes in cancer establishment [1]," scientists in Ferrara, Italy report (see also Hematology).
"Dietary folate or supplements (e.g., folic acid) must be fully reduced by dihydrofolate reductase (DHFR) before entering cell metabolism [1]. DHFR is responsible for dihydrofolate (DHF) to tetrahydrofolate (THF) conversion, as well as for assisting the generation of additional partially reduced folates (i.e., methylene-THF and formyl-THF), which are then transformed into the fully active folate (i.e., methyl-THF) ...