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Article: Reports summarize breast cancer research from University of Adelaide.(Report)
- Article from:
- Cancer Weekly
- Article date:
- September 22, 2009
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"There is emerging evidence that the balance between estrogen receptor-alpha (ER alpha) and androgen receptor (AR) signaling is a critical determinant of growth in the normal and malignant breast. In this study, we assessed AR status in a cohort of 215 invasive ductal breast carcinomas," scientists writing in the journal Cancer Research report (see also Breast Cancer).
"A.R and ER alpha were coexpressed in the majority (80-90%) of breast tumor cells. Kaplan-Meier product limit analysis and multivariate Cox regression showed that AR is an independent prognostic factor in ER alpha-positive disease, with a low level of AIR (less than median of 75% positive cells) ...