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Article: Nutlin-Induced Apoptosis Analyzed Using Roche's xCELLigence System and RealTime ready Focus Panels.
- Article from:
- Cancer Weekly
- Article date:
- September 22, 2009
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The p53 tumor suppressor, a transcription factor that activates or inhibits hundreds of genes, either directly or indirectly, triggers a variety of cellular effects and plays a central role in the cellular defense against cancer. One of the main approaches for pharmacological intervention is to activate wild-type p53 in cancer cells by blocking MDM2 from binding to p53. Scientists have recently identified nutlins - small molecules inhibiting p53/MDM2 interaction - which represent valuable tools for studying p53 regulation and facilitating the development of cancer therapies (see also Roche).
In a recent study (1) Scheuermann et al. evaluated a method for ...