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Article: The Uses of Asymmetry Cancer Stem Cells Fueled by P53 Loss, Cell Division Changes.
- Article from:
- BIOWORLD Today
- Article date:
- September 21, 2009
- Author:
CopyrightCOPYRIGHT 2009 A Thomson Healthcare Company. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Byline: Anette Breindl, Science Editor
In the Sept 18, 2009, issue of Cell, a team of Italian and Swiss researchers described part of how cancer stem cells keep on going: Loss of the tumor suppressor p53 shifts the way in which they divide toward a mechanism that keeps producing more cancer stem cells.
Cancer stem cells -- and for that matter, stem cells generally, can divide in different ways. They can divide asymmetrically, producing one cancer stem cell and one tumor cell, but they also can divide symmetrically, turning into two daughter stem cells.
The basic finding of the paper, co-corresponding author Pier Giuseppe Pelicci told BioWorld ...