Article: New atrial fibrillation research from Massachusetts General Hospital discussed.(Report)

According to recent research from the United States, "Mutations in several ion channel genes have been reported to cause rare cases of familial atrial fibrillation (AF). The purpose of this study was to determine the genetic basis for AF in a family with autosomal dominant AF."

"Family members were evaluated by 12-lead ECG, echocardiogram, signal-averaged P-wave analysis, and laboratory studies. Fourteen family members in AF-324 were studied. Six individuals had AF, with a mean age at onset of 32 years (range 16-59 years). Compared with unaffected family members, those with AF had a Longer mean QRS duration (100 vs 86 ms, P = .015) but no difference in the ...

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