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Article: Research data from University of Florida, Medical Department update understanding of biological chemistry.
- Article from:
- Chemicals & Chemistry
- Article date:
- October 2, 2009
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"Aldosterone increases renal tubular Na+ absorption in large part by increasing transcription of the epithelial Na+ channel alpha-subunit (alpha-ENaC) expressed in the apical membrane of collecting duct principal cells. We recently reported that a complex containing the histone H3K79 methyltransferase disruptor of telomeric silencing-1 (Dot1) associates with and represses the alpha-ENaC promoter in mouse inner medullary collecting duct mIMCD3 cells, and that aldosterone acts to disrupt this complex and its inhibitory effects (Zhang, W., Xia, X., Reisenauer, M. R., Rieg, T., Lang, F., Kuhl, D., Vallon, V., and Kone, B. C. ( 2007) J. Clin. Invest. 117, 773-783)," scientists ...