Article: Physiological mechanisms of sexual dysfunction side effects associated with antidepressant medication.

The effects of psychotropic medications on human sexual functioning have been recognized for years. Such effects are now receiving even more attention because antidepressant medications, especially the selective serotonin reuptake inhibitor (SSRI) agents, have been accompanied by greater incidence of sexual side effects than has been expected, based on data from prerelease studies (Gitlin, 1994; Greenberg, 1971; Herman et al., 1990; Kline, 1989; Monteiro, Noshirvani, Marks, & Lelliott, 1987; Patterson, 1993; Singh, 1961; Zajecka, Fawcett, Schaff, Jeffriess, & Guy, 1991).

Many case reports and results of a few controlled studies have documented the associations among ...

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