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Article: Researchers' work from University of Barcelona focuses on proteomics.
- Article from:
- Biotech Week
- Article date:
- October 7, 2009
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According to a study from Spain, "ECP (eosinophil cationic protein) is an eosinophil secretion protein with antipathogen activities involved in the host immune defence system. The bactericidal capacity of ECP relies on its action oil both the plasma membrane and the bacterial wall."
"Ill a search for the structural determinants of ECP antimicrobial activity, we have identified an N-terminal domain (residues 1-45) that retains most of ECP's membrane-destabilizing and antimicrobial activities. Two sections of this domain, ECP-(1-19) and ECP-(24-45), have also been evaluated. All three peptides bind and partially insert into lipid bilayers, inducing aggregation of ...