Article: New data from Y.M. Liu et al illuminate research in cancer.

"Tumor metabolism and bioenergetics have become important topics for cancer research and are promising targets for anticancer therapy. Although glucose serves as the main source of energy, proline, an alternative substrate, is important, especially during nutrient stress," scientists in the United States report (see also Cancer).

"Proline oxidase (POX), catalyzing the first step in proline catabolism, is induced by p53 and can regulate cell survival as well as mediate programmed cell death. in a mouse xenograft tumor model, we found that POX greatly reduced tumor formation by causing G(2) cell cycle arrest. Furthermore, immunohistochemical staining showed ...

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