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Article: Research from J.T. Vogelstein and co-researchers in the area of biophysics published.
- Article from:
- Physics Week
- Article date:
- October 6, 2009
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"As recent advances in calcium sensing technologies facilitate simultaneously imaging action potentials in neuronal populations, complementary analytical tools must also be developed to maximize the utility of this experimental paradigm. Although the observations here are fluorescence movies, the signals of interest-spike trains and/or time varying intracellular calcium concentrations-are hidden," scientists in the United States report.
"Inferring these hidden signals is often problematic due to noise, nonlinearities, slow imaging rate, and unknown biophysical parameters. We overcome these difficulties by developing sequential Monte Carlo methods (particle ...