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Article: Studies by S. Tunca and co-authors describe new findings in antibiotics.(Report)
- Article from:
- Biotech Week
- Article date:
- October 14, 2009
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"The dmdR1 gene of Streptomyces coelicolor encodes an important regulator of iron metabolism. An antiparallel gene (adm) homologous to a development-regulated gene of Streptomyces aureofaciens has been found to overlap with dmdR1," scientists in Leon, Spain report (see also Antibiotics).
"Both proteins DmdR1 and Adm are formed in solid and liquid cultures of S. coelicolor A3(2). The purpose of this study was to assess possible interaction between the products of these two antiparallel genes. Two mutants with stop codons resulting in arrested translation of either DmdR1 or Adm were obtained by gene replacement and compared with a deletion mutant (Delta dmdR1/adm) ...