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Article: Studies from J. Thomas et al add new findings in the area of proteomics.
- Article from:
- Biotech Week
- Article date:
- October 14, 2009
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"Protein-protein interactions are mediated by complementary amino acids defining complementary surfaces. Typically not all members of a family of related proteins interact equally well with all members of a partner family; thus analysis of the sequence record can reveal the complementary amino acid partners that confer interaction specificity," investigators in the United States report (see also Proteomics).
"This article develops methods for learning and using probabilistic graphical models of such residue ''cross-coupling'' constraints between interacting protein families, based on multiple sequence alignments and information about which pairs of proteins are ...
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