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Article: Studies in the area of life sciences reported from National Cheng-Kung University, Medical Department.
- Article from:
- Blood Weekly
- Article date:
- October 15, 2009
CopyrightCOPYRIGHT 2009 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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According to a study from Tainan, Taiwan, "Rhodostomin (Rho) is a snake venom protein containing an RGD motif that specifically inhibits the integrin-binding function. Rho produced in Pichia pastoris inhibits platelet aggregation with a K-I of 78 nM as potent as native Rho."
"In contrast, its D51E mutant inhibits platelet aggregation with a K-I of 49 mc M. Structural analysis of Rho and its D51E mutant showed that they have the same tertiary fold with three two-stranded antiparallel beta-sheets. There are no structural backbone differences between the RG[D/E] loop which extends outward from the protein core and the RG[D/E] sequence at its apex in a four-residue ...
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Article: National Cheng-Kung University ...
Electronics Newsweekly;
January 14, 2009 ;
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... ... Chen and colleagues, National Cheng-Kung University. The researchers ... contact L.Y. Chen, National Cheng Kung University, Dept. of Electrical ... VoltageSemiconductors, National Cheng-Kung University. This article was ...
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