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Article: Researchers from Burnham Institute for Medical Research describe findings in phosphatase.
- Article from:
- Blood Weekly
- Article date:
- October 15, 2009
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Investigators publish new data in the report 'Identification and characterization of novel tissue-nonspecific alkaline phosphatase inhibitors with diverse modes of action.' "Tissue-nonspecific alkaline phosphatase (TNAP) is a ubiquitous enzyme expressed at high levels in bone, liver, and kidney. It appears involved in dephosphorylation of numerous phosphate monoesters, but only 2 of them, pyrophosphate and pyridoxal phosphate, have yet been unequivocally documented," scientists in the United States report (see also Phosphatase).
"Discovery and characterization of other substrates could be considerably facilitated if specific and potent modulators of TNAP ...