Article: Research reports from University of Bari provide new insights into apoptosis.

According to recent research published in the journal Gastroenterology, "Deoxycholate (DC) has proapoptotic and tumorigenic effects in different cell types of the gastrointestinal tract. Exposure of BHK-21 (stromal) cells to DC induces Ca2+ entry at the plasma membrane, which affects intracellular Ca2+ signaling."

"We assessed whether DC-induced increases in [Ca2+] can impinge on plasma membrane properties (eg, ionic conductances) involved in cell apoptosis. Single- and double-barreled microelectrodes were used to measure membrane potential (V-m) and extracellular [K+] in BHK-21 fibroblasts and Caco-2 colon carcinoma cells. Apoptosis was assessed by Hoechst ...

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